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Designed to Help Keep Cholesterol Low

LEQVIO is uniquely designed to help get and keep bad cholesterol (LDL-C) low for up to 6 months per injection, after the two initial doses

The liver plays a key role in clearing bad cholesterol (LDL-C) from the blood, but certain proteins in the liver can interfere with this process. LEQVIO uses the body's natural processes to prevent many of these proteins from forming in the first place, which can result in lower bad cholesterol.

Liver

Talk to your health care provider to learn how LEQVIO works differently than other cholesterol-lowering treatments


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LEQVIO Clinical Study Results

LEQVIO delivers effective and long-lasting reduction of bad cholesterol (LDL-C)

In a clinical study of people with known heart disease on a statin who needed more help lowering bad cholesterol (LDL-C), people given LEQVIO lowered their bad cholesterol by over 50% and kept it low during each 6-month dosing interval vs placebo (a substance that doesn't contain any medication).

Leqvio plus a statin lowered cholesterol by over 50% and kept it low.

Individual results may vary.

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Clinical study information

These results are based on a study in which 1561 patients with atherosclerotic cardiovascular disease (ASCVD) were on a maximally tolerated statin with or without another cholesterol-lowering treatment—in addition to LEQVIO (781 patients) or a placebo (780 patients). Cholesterol levels were measured at the start of the study and compared with cholesterol levels 17 months later. Sixty percent of the patients were 65 years or older.

LEQVIO helped patients reach their goal

In clinical studies, 8 out of 10 people taking Leqvio plus a statin achieved their recommended cholesterol goal.

In a clinical study,

people taking LEQVIO + statin achieved the recommended cholesterol goal of <70 mg/dL vs 2 out of 10 people taking statin + placebo at 17 months

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Works with your current statin

LEQVIO doesn't replace healthy food choices, regular physical activity, or a statin. Instead, it works with your statin to reduce your bad cholesterol even further.

Safety information from multiple studies

In 3 clinical studies with more than 3500 people, 1833 people were treated with LEQVIO and 1822 people were treated with placebo.

  • The most common side effects of LEQVIO were: injection site reaction (including pain, redness, and rash), joint pain, urinary tract infection, diarrhea, chest cold, pain in legs or arms and shortness of breath

  • Side effects leading to discontinuation occurred in 2.5% of people taking LEQVIO vs 1.9% with placebo

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DOSING & ADMINISTRATION

Talk to your health care provider to see if two doses a year of
LEQVIO is right for you.*

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*Two doses a year after two initial doses.

INDICATION AND IMPORTANT SAFETY INFORMATION

COLLAPSE

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IMPORTANT SAFETY INFORMATION

The most common side effects of LEQVIO were: injection site reaction (including pain, redness, and rash), joint pain, urinary tract infection, diarrhea, chest cold, pain in legs or arms and shortness of breath.

These are not all the possible side effects of LEQVIO. Ask your health care provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-10881-800-FDA-1088.

Please see LEQVIO full Prescribing Information.

What is LEQVIO?

LEQVIO (inclisiran) is an injectable prescription medicine used along with diet and other lipid-lowering medicines in adults who need additional lowering of "bad" cholesterol (LDL-C) and have known cardiovascular disease and/or heterozygous familial hypercholesterolemia (HeFH), an inherited condition that causes high levels of LDL-C. It is not known if LEQVIO can decrease problems related to high cholesterol, such as heart attacks or stroke.

Please see LEQVIO full Prescribing Information.